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Lastly, clonidine boosts neuraxial opioids and, in combination with fentanyl, interacts in an additive way, which might lessen the dose of every component by 60% for postoperative analgesia.Jun ten, 2024 · If clonidine therapy will be to get replaced by a β-blocker, hold off administration of the β-blocker for a number of days after clonidine t